Adam Samer al-Ghoul, 8, and Basil Suleiman Abu al-Wafa, 15, were fatally shot by Israeli forces during an 18-hour raid in Jenin that also saw major destruction in the city and its refugee camp on Wednesday.
The Palestinian Health Ministry confirmed the children's deaths and video of the killings has spread on social media.
Nihad Awad, executive director of the Council on American-Islamic Relations, urged US President Joe Biden to condemn the killings.
Biden "should condemn the killing of Palestinian children in the same way that he rightly condemns violence targeting others," he said in a statement.
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"The killing of Palestinian children by Israel’s far-right apartheid government will continue until the decades-long dehumanization of the Palestinian people and the systematic denial of their rights by the Global North comes to an end," Awad stressed.
"Our nation’s leaders must finally recognize that Palestinians are human beings who do have rights, including the right to life," he added.
Source: Anadolu Agency